Impaired Degradation of Prostaglandins and Thromboxane in Zellweger Syndrome
نویسندگان
چکیده
منابع مشابه
Peroxisomal chain-shortening of thromboxane B2: evidence for impaired degradation of thromboxane B2 in Zellweger syndrome.
We have shown that rat liver peroxisomes can chain-shorten prostaglandins to dinor- and tetranor-metabolites. In a recent in vivo study we could demonstrate that peroxisomes are of major importance for chain-shortening of prostaglandin F2 alpha in humans (1991, Diczfalusy et al. J. Clin. Invest. 88:978-984). This was shown by identifying the major urinary metabolites of radiolabeled prostagland...
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Much work has recently focused upon the cellular involvement of the mesangium in glomerular inflammation and fibrosclerosis. A host of mediators of inflammation have been identified and their actions studied in mesangial cell cultures [1]. The recent identification of functional receptors for prostaglandins (PG) and thromboxane A2 (TxA2) in cultured glomerular mesangial cells [2, 3] has prompte...
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PURPOSE To determine characteristic MR imaging features of Zellweger syndrome. METHODS Clinical records, laboratory records, and MR studies of six patients with Zellweger syndrome were reviewed retrospectively. MR studies were examined for the state of myelination; the presence, extent, and morphologic appearance of cerebral cortical anomalies; the status of the cerebellar cortex, basal nucle...
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The capacity of cerebral arteries to synthesize prostaglandins was studied by 2 procedures. In one, bovine cerebral arteries were incubated with 0.1 nC (l-C)-arachidonic acid for 3 hours. Using thin layer chromatography, 5 products of this arachidonic acid were isolated: prostaglandin Ê (PGE2), prostaglandin F2o (PGF2o), 6-keto prostaglandin Flo (6-keto PGFla), prostaglandin D2 (PGD2), and thro...
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Alterations in the synthesis of thromboxane A2 (TxA2) and prostacyclin have been implicated in the development of atherosclerosis. We measured the amounts of the degradation products of these substances, TxB2 and 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), respectively, as well as PGE2, that were synthesized by slices and the luminal surfaces of aortas from rabbits fed either a control die...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1994
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199410000-00006